A lot of thought was put into this movie, and effort, considering most was done with stop-motion-animation. The one liners were what made it all work together, and the bickering between the dogs. It was just great.
The dogs spoke English, the humans Japanese. It gives the film a unique perspective and the audience, for the most part, views the film through the eyes of the dogs. The plot had several layers, the quest to find the dog Spot, and then the conspiracy back with the humans, regarding finding a cure for the ailments the dogs are suffering.
Overall, it was a delightful movie. The dialogue, plot, and detailed scenes, all worked together to tell the story well and keep the audience entertained. It was a bit dark, and had a bit more gore in it than I usually like in my animated movies, but the other aspects made up for it.